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- Parent Category: Cancer
- Category: Treatments
by Michael Brown
Semi-porous hollow nanospheres could improve the delivery of anti-leukaemia drugs in the body claim scientists in China.
L-asparaginase is a very effective anti-tumour enzyme used to treat leukaemia. However, its harmful side effects limit its clinical use. Chemical modification of the enzyme results in a large loss of activity and previous drug delivery systems have been unable to prevent leakage into the blood.
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- Parent Category: Cancer
- Category: Research
Researchers have found that one particularly aggressive type of blood cancer, mixed lineage leukemia (MLL), has an unusual way to keep the molecular motors running. The cancer cells rely on the normal version of an associated protein to stay alive.
MLL happens when a piece of chromosome 11 breaks off at the normal MLL-associated gene. The broken gene attaches itself to another chromosome, resulting in a fusion protein that eventually causes uncontrolled growth of blood cells.
Read more: Cells of Aggressive Leukemia Hijack Normal Protein to Grow, According to Penn Study
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- Parent Category: Cancer
- Category: Research
by Hilary Parker
A team of scientists from Princeton University and The Cancer Institute of New Jersey has embarked on a major new project to unravel the secret lives of cancer cells that go dormant and self-cannibalize to survive periods of stress. The work may help produce new cancer therapies to stem changes that render cancer cells dangerous and resistant to treatment.
"We want to know: What role is this self-cannibalization playing in the middle of a tumor?" said team member Hilary Coller, an assistant professor of molecular biology at Princeton. "To treat cancer, it may be that you want to get rid of this ability in tumor cells, so we're searching for inducers and inhibitors of this process."
Read more: Research Team Targets Self-Cannibalizing Cancer Cells
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- Parent Category: Cancer
- Category: Research
A protein acting as a switch to activate the cell death process may prove to be an effective targeted treatment for killing cancer cells.
University of Michigan researchers discovered that the protein called RIP plays a role in mediating both the life and death of squamous cell carcinoma cancer cells, said Yvonne Kapila, associate professor, Department of Periodontics and Oral Medicine at the School of Dentistry.
This is key because cancer cells elude the normal cell death process. If that process could be activated artificially by a targeted introduction of RIP into cancer patients, those cells could be destroyed before they circulate out of control in the body, Kapila said.
Read more: Lights Out: A Protein May Switch off Cancer Cells
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- Parent Category: Cancer
- Category: Research
By Steve Benowitz
Researchers at the Ludwig Institute for Cancer Research (LICR) at the University of California, San Diego School of Medicine and Moores UCSD Cancer Center have shown one way in which gliomas, a deadly type of brain tumor, can evade drugs aimed at blocking a key cell signaling protein, epidermal growth factor receptor (EGFR),that is crucial for tumor growth. In a related finding, they also proved that a particular EGFR mutation is important not only to initiate the tumor, but for its continued growth or “maintenance” as well.
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- Parent Category: Cancer
- Category: Research
Drinking green tea could modulate the effect of smoking on lung cancer. Results of this hospital-based, randomized study conducted in Taiwan were presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer, held here from Jan. 11-14, 2010.
“Lung cancer is the leading cause of all cancer deaths in Taiwan,” said I-Hsin Lin, M.S., a student at Chung Shan Medical University in Taiwan. “Tea, particularly green tea, has received a great deal of attention because tea polyphenols are strong antioxidants, and tea preparations have shown inhibitory activity against tumorigenesis.”
Read more: Green Tea Could Modify the Effect of Cigarette Smoking on Lung Cancer Risk
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