Asher Mullard

No need for Klf4 and c-Myc when you reprogramme with Esrrb

Since the recent discovery that the transcription factors Oct4, Sox2, c-Myc and Klf4 can convert fibroblasts into induced pluripotent stem cells1, researchers have struggled to come to grips with the ins and outs of reprogramming. Now Huck-Hui Ng from the Genome Institute of Singapore and his colleagues have found that another reprogramming factor — Esrrb — can be used in place of Klf4 and c-Myc2. This discovery may help researchers better understand the basis of this process.

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